This group is principally interested in the biological effects and targeting for therapeutic purposes of the non-canonical conformations of nucleic acids.
We study the presence and the physiological and pathological roles of G-quadruplexes and i-Motifs in several viruses (e.g. HIV, HSV, arboviruses), bacteria (Mycobacterium), cancers (liposarcoma) and neurodegenerative diseases (X-linked dystonia parkinsonism) .
We aim at targeting non-canonical nucleic acids to develop antiviral, antibacterial, anticancer drugs and to cure neurodegenerative diseases
We apply techniques in vitro (circular dichroism, fluorescence resonance energy transfer, Taq polymerase stop assay) and in cells (pull-down coupled with mass spectrometry, immunofluorescence, proximity ligation assay, FISH), including genome-wide techniques such as ChIP-seq, CUT&Tag, RNA-seq.